Lab. Seminar
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Á¦°¡ ¼±Á¤ÇÑ ³í¹®Àº ÀÛ³â Science immunology¿¡ ÃâÆÇ µÈ
"RELMa-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection" ÀÔ´Ï´Ù.
ÀÌ ³í¹®¿¡¼´Â ÈçÈ÷ M2 typeÀ̶ó°í ºÒ¸®´Â alternatively activated macrophage(AAM) type¿¡ Æ÷Ä¿½º¸¦ ¸ÂÃß¾ú½À´Ï´Ù.
±×Áß¿¡¼µµ resistin-like molecule(RELMa)ÀÇ ¹ßÇöÀÌ macrophageÀÇ ¿ªÇÒ¿¡ ¾î¶°ÇÑ ¿µÇâÀ» ¹ÌÄ¡´ÂÁö ¾Ë¾Æº¸°íÀÚ ÇÏ¿´À¸¸ç,
°á°úÀûÀ¸·Î RELMa-expressing macrophage´Â helminth infection »óȲ¿¡¼ lung damage¸¦ ¿ÏȽÃÅ°´Âµ¥ Áß¿äÇÑ ¿ªÇÒÀ» ÇÔÀ» È®ÀÎÇÏ¿´½À´Ï´Ù.
ÀÌ ³í¹®À» ¼±Á¤ÇÑ ÀÌÀ¯´Â,
- Lung macrophage¿¡ ´ëÇØ °øºÎÇÏ°íÀÚ
- macrophage¿¡¼ RELMa ¹ßÇöÀÌ inflammation °¨¼Ò ¹× wound healingÀ» Áõ°¡½ÃÅ°´Â Ãø¸éÀ» º¼¶§, Á¦°¡ ÁøÇàÇÏ´Â ½ÇÇè¿¡µµ ÀÌ maker¸¦ ÀÌ¿ëÇϸé ÁÁÀ» °Í °°´Ù´Â »ý°¢À» ÇÏ¿´½À´Ï´Ù.
- ¶ÇÇÑ ÀÌ ³í¹®¿¡¼ »ç¿ëµÈ ½ÇÇ轺Ŵ ¹× °¢Á¾ ½ÇÇè¹æ¹ýµéÀ» Âü°íÇÏ°íÀÚ
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https://immunology.sciencemag.org/content/4/35/eaau3814
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"Porcine Reproductive and RespiratorySyndrome Virus enhances self-replication via AP-1−dependent induction of SOCS1"
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PRRSV°¡ ¼¼Æ÷³»¿¡¼ replicationÇÏ´Â °úÁ¤¿¡¼ SOCS1 ºÐÀÚ°¡ Áõ°¡ÇÏ..
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À̹ø ÁÖ Á¦°¡ ¹ßÇ¥ÇÒ ³í¹®Àº¿ÃÇØMucosal Immunology¿¡ °ÔÀçµÈ °ÍÀ¸·Î,
Á¦¸ñÀº 'Regulatory T cells control the dynamic and site-specific polarization of total CD4 T cells following Salmonella infection.'ÀÔ´Ï´Ù.
inflammation °ú mucosal homeostasis¸¦ Á¶ÀýÇÑ´Ù°í ¾Ë·ÁÁøT..
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