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Naringenin Enhances the Antitumor Effect of Therapeutic Vaccines by Promoting Antigen Cross-Presentation À̸ç

Áö³­ÇØ 12¿ù¿¡ Jounal of immunology ¿¡ ÃâÆǵǾú½À´Ï´Ù. 

½Ä¹° À¯·¡ÀÇ metaboliteÀÇ ÇÑ Á¾·ùÀÎ FlavonoidsÀÎ NaringeninÀ̶ó´Â ¹°ÁúÀÌ Ç׿øÀÇ cross-presentationÀ» Çâ»ó ½ÃÅ°´Â °ÍÀ» º¸¿©ÁÖ°í ÀÖÀ¸¸ç, 

ÁÖ¿ä ±âÀÛÀ¸·Î, lipid peroxidationÀ» À̾߱âÇÏ°í ÀÖÀ¸¸ç À̸¦ ÅëÇØ Á¦°¡ ÁøÇàÇÏ°í ÀÖ´Â ½ÇÇè°úµµ ¸Å¿ì À¯»çÇÏ°Ô Ç׿øÀÇ cytosol À̵¿À» º¸¿©ÁÖ°í ÀÖ½À´Ï´Ù. 

PST¸¦ ÀÌ¿ëÇÑ ½ÇÇè°úµµ À¯»çÇÑ ºÎºÐÀÌ ÀÖÀ¸¸é¼­µµ ´Ù¸¥ ºÎºÐÀÌ ÀÖ¾î, ³í¹® ÀÛ¼º½Ã Âü°í°¡ µÉ ºÎºÐµéÀÌ ÀÖÀ¸¸ç
ÃÖ±Ù ÁøÇà ÁßÀÎ fatty acid synthesis inhibition°ú cross-presentation ½ÇÇè¿¡µµ ¾ÆÀ̵ð¾î¸¦ ¾òÀ» ¼ö ÀÖÀ» °Í °°½À´Ï´Ù. 

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³í¹® ¸µÅ© : https://www.jimmunol.org/content/early/2019/12/21/jimmunol.1900278
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