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2016³â Cell reports¿¡ °ÔÀçµÈ "IL-4 induces metallothionein 3- and SLC30A4-dependent increase in intracellular Zn2+ that promotes pathogen persistence in macrophages"¶ó´Â Á¦¸ñÀÇ ³í¹®À¸·Î

IL-4¿¡ ÀÇÇÑ macrophageÀÇ alternative activation »óȲ¿¡¼­ MT3(metallothionein 3)¿Í Zn2+ ionÀÇ »óÈ£ÀÛ¿ë°ú ÀÌ·ÎÀÎÇÑ macrophageÀÇ phagolysosome ³»ºÎ¿¡¼­ intracellular pathogenÀÇ persistanceÀÇ Á¶ÀýÀ» ´Ù·é ³í¹®À¸·Î,
myeloid cell¿¡¼­ IL-4 stimulation¿¡ ÀÇÇØ intracellular pathogenÀÌ ¾î¶°ÇÑ ¿µÇâÀ» ¹Þ´ÂÁö °øºÎÇϴµ¥ µµ¿òÀÌ µÉ °Í °°¾Æ ¼±Á¤ÇÏ°Ô µÇ¾ú½À´Ï´Ù.

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1-s2.0-S221112471631138X-main.pdf (4.98MB)
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¾È³çÇϼ¼¿ä. À̹øÁÖ ¹ßÇ¥ÀÚÀÎ ÁÖ¿µÁØÀÔ´Ï´Ù. Á¦°¡ ¹ßÇ¥ÇÒ ³í¹®Àº Áö³­´Þ Immunity¿¡ ½Ç¸° "Proliferating Transitory T Cells with an Effector-like Tran LCMV chronic infection ½Ã¿¡ CX3CR+ CD8+ T cellÀÌ viral control¿¡ Áß¿äÇÏ´Ù´Â °ÍÀ» ¹àÈù ³í¹®ÀÔ´Ï´Ù. Rafi ahmed ±×·ì¿¡¼­ ³ª¿Â ³í¹®À¸·Î LCMV a..