¾È³çÇϼ¼¿ä. À̹ø ÁÖ ¹ßÇ¥ÀÚ µµ¿µÀÔ´Ï´Ù.
Á¦°¡ ¼±Á¤ÇÑ ³í¹®Àº 2022³â 4¿ù nature communications¿¡ °ÔÀçµÈ “FcyR-mediated SARS-CoV-2 infection of monocytes activates inflammasome”ÀÔ´Ï´Ù.
SARS-CoV-2´Â ÀϺΠȯÀÚ¿¡°Ô ±Þ¼º È£Èí °ï¶õ°ú »ç¸ÁÀ» À¯¹ßÇÒ ¼ö ÀÖ½À´Ï´Ù. ÀÌ·¯ÇÑ ½É°¢ÇÑ COVID-19 Áõ¼¼´Â»ó´çÇÑ ¿°Áõ¹ÝÀÀ°ú °ü·ÃÀÌ ÀÖÁö¸¸, ¾î¶»°Ô ¿°ÁõÀÌ À¯¹ßµÇ´ÂÁö´Â ¸íÈ®ÇÏÁö ¾Ê½À´Ï´Ù.
º» ³í¹®¿¡¼´Â pyroptosis¿¡ ÀÇÇØ monocyte°¡ »ç¸êÇÏ¸é¼ °ÇÑ ¿°Áõ¹ÝÀÀÀ» ÀÏÀ¸ÄÑ ÁßÁõ ¹× »ç¸ÁÀ» À¯¹ßÇÒ ¼öÀÖ´Ù°í ÁÖÀåÇϸç, ±× ±âÀüÀ» ¹àÇû½À´Ï´Ù.
¸ÕÀú, SARS-CoV-2 °¨¿° ȯÀÚ, ƯÈ÷ severeÇÑ È¯ÀÚµéÀÇ Ç÷¾×¿¡¼ monocyte pyroptosis¿Í °ü·ÃµÈ ÁöÇ¥µéÀ» È®ÀÎÇß°í, imaging flow cytometry¸¦ È°¿ëÇÏ¿© ASC, caspase-1, pyroptosis-specific ¸¶Ä¿µéÀ» ÅëÇØ monocyteÀÇinflammasomeÀÌ È°¼ºÈµÇ¸é¼ pyroptosis°¡ À¯µµµÇ°í IL-1°ú IL-18°ú °°Àº »çÀÌÅäÄ«ÀÎÀÌ release µÊÀ» È®ÀÎÇß½À´Ï´Ù. ´õ ³ª¾Æ°¡, inflammasomeÀÇ È°¼ºÀº SARS-CoV-2¿¡ °¨¿°µÈ monocyte¿Í macrophage¿¡ ÀÇÇØ triggerµÊÀ» È®ÀÎÇÏ¿´°í, monocyteÀÇ °æ¿ì, anti-spike antibody¿¡ ÀÇÇØ opsonizedµÈ SARS-CoV-2°¡ monocyte Ç¥¸é¿¡ ¹ßÇöµÈ CD16(FcyR3A)À» ÅëÇØ °¨¿°À» ÀÏÀ¸Å²´Ù´Â °ÍÀ» ¹àÇû½À´Ï´Ù. ¶ÇÇÑ, SARS-CoV-2¿¡ °¨¿°µÈ monocyteÀº ¹ÙÀÌ·¯½º¸¦ º¹Á¦´Â ÇÏÁö¸¸ ´õ ÀÌ»óÀÇ °¨¿°À» ÀÏÀ¸Å°Áö ¾Ê´Â °ÍÀ» È®ÀÎÇß½À´Ï´Ù.
ÀÌ·¯ÇÑ °á°ú¸¦ Á¾ÇÕÇϸé, monocyte¿Í macrophage¿¡ ÀÇÇÑ Ç×ü ¸Å°³ SARS-CoV-2 uptake°¡ inflammasome È°¼ºÀ» À¯µµÇÏ¿© °¨¿° ¹ÙÀÌ·¯½º »ý¼ºÀ» Áß´ÜÇÏ´Â pyroptosis¸¦ ÀÏÀ¸Å°Áö¸¸ Àü½Å ¿°Áõ¹ÝÀÀÀ» À¯¹ßÇÏ¿© ½É°¢ÇÑCOVID-19 Áõ¼¼¸¦ ¾ß±âÇÔÀ» ½Ã»çÇÕ´Ï´Ù.
COVID-19ÀÇ pathogenesis¿¡ ´ëÇØ °øºÎÇÏ°íÀÚ ¼±Á¤ÇÏ°Ô µÇ¾ú½À´Ï´Ù.
°¨»çÇÕ´Ï´Ù.
³í¹®¸µÅ©: https://www.nature.com/articles/s41586-022-04702-4#Sec30