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Salmonella T3SS-2 virulence enhances gut-luminal colonization by enabling chemotaxis-dependent exploitation of intestinal inflammation'ÀÔ´Ï´Ù.
¿°Áõ »óȲ¿¡¼ Àå¿¡¼ »ý¼ºµÇ´Â inflammation-dependent nutrients´Â pathogen growth ¶Ç´Â antimicrobial activities¿¡ ¸ðµÎ ÀÌ¿ëµÉ ¼ö ÀÖ½À´Ï´Ù. À̶§ pathogenÀÌ Àå ³»ºÎ¿¡¼ advantageous niche¸¦ ȹµæÇÏ´Â µ¥ ÀÌ¿ëµÇ´Â Tsr-dependent chemotaxisÀº pathogen beneficialÇÑ ¿ªÇÒÀ» ¼öÇàÇÏ´Â ¹Ý¸é, ƯÁ¤ »óȲ¿¡¼´Â ¿ÀÈ÷·Á ºÒ¸®ÇÏ°Ô ÀÛ¿ëÇÕ´Ï´Ù. À̸¦ ¹ÙÅÁÀ¸·Î º» ¿¬±¸¿¡¼´Â ¿°Áõ »óȲ¿¡¼
Salmonella Typhimurium°¡ Tsr-mediated chemotaxisÀÇ context-dependent fitness benefitÀ» Á¦°ø¹Þ´Â µ¥ T3SS-2 ±â´É ¿©ºÎ°¡ Áß¿äÇÑ ¿ªÇÒÀ» ÇÑ´Ù´Â °ÍÀ» ¹àÇû½À´Ï´Ù.
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tsr°ú °ü·ÃÇÑ fitness benefit¿¡ prophage Gifsy3°¡ ÀÎÄÚµùÇÏ´Â virulence factors°¡ °ü¿©ÇÔÀ» ¹àÇû½À´Ï´Ù. tsr-deficient ½Ã¿¡ 2ÀÏÂ÷ºÎÅÍ gut-luminal colonization°¡ °¨¼ÒÇÏ´Â °ÍÀ» ÅëÇØ
tsrÀÇ fitness advantage Á¦°ø ¿©ºÎ¸¦ È®ÀÎÇß½À´Ï´Ù. ¶ÇÇÑ, Gifsy3 mutants¿¡¼´Â ¾Õ¼± °á°ú¿Í ´Ù¸£°Ô
tsr-deficient ½Ã¿¡µµ WT°ú µ¿ÀÏÇÑ gut-luminal colonizationÀ» ³ªÅ¸³»´Â °ÍÀ» È®ÀÎÇß½À´Ï´Ù.
¶ÇÇÑ, T3SS-2 ±â´É ¿©ºÎ¿¡ µû¶ó Tsr-mediated chemotaxisÀÇ °áÇÌÀÌ S.TmÀÇ »ýÁ¸¿¡ À¯¸®ÇÒ ¼ö ÀÖ´Ù´Â °ÍÀ» ¹àÇû½À´Ï´Ù. T3SS-2 virulence°¡ gut-luminal pathogenÀÌ antimicrobial effect¿¡ ´ëÀÀÇϵµ·Ï ÇÏ´Â ¹Ý¸é, T3SS-2ÀÇ °áÇÌÀº chemotaxis¸¦ ÁøÇà ÁßÀÎ
tsr-proficient ¼¼Æ÷µéÀÇ »ç¸êÀ» ÃÊ·¡ÇÒ °ÍÀ̶ó´Â °¡¼³À» ¼¼¿ì°í, T3SS-2ÀÇ
ssaV°¡ °áÇÌµÈ ±ÕÁÖ¸¦ °¨¿°½ÃÄÑ ¿ÀÈ÷·Á tsr-proficient cellsÀÌ µµÅµǴ °ÍÀ» È®ÀÎÇß½À´Ï´Ù.
´ÙÀ½À¸·Î, host factors Áß¿¡¼µµ NLRC4 inflammasome ¹× neutrophilsÀÌ
tsr-proficient cellsÀÇ fitness loss¿¡ ±â¿©ÇÑ´Ù´Â °ÍÀ» ¹àÇû½À´Ï´Ù. NLRC4 knockout ¹× neutrophils depletion mice¸¦ »ç¿ëÇØ ÀÌ·¯ÇÑ Çö»ó¿¡ ±â¿©ÇÏ´Â NLRC4 inflammasome ¹× neutrophils°¡ Tsr chemotaxis¿¡ ºÎÁ¤ÀûÀÎ ¿µÇâÀ» ¹ÌÄ¡°í, ÀÌ´Â T3SS-2 virulence¿¡ ÀÇÇØ ¿Ï鵃 ¼ö ÀÖÀ½À» ¹àÇû½À´Ï´Ù.
ÃÖÁ¾ÀûÀ¸·Î, Tsr-mediated chemotaxis selective¿¡ ÀÖ¾î resident microbiotaÀÇ ¿ªÇÒÀ» ¾Ë¾Æº¸±â À§ÇØ germ-free mice¿¡¼ ½ÇÇèÀ» ¼öÇàÇß°í NLRC4 knockout ¹× neutrophils depletion ½Ã¿¡µµ À§¿Í µ¿ÀÏÇÑ °á°ú¸¦ ¾òÀ½À¸·Î½á
SalmonellaÀÇ Tsr-mediated chemotaxis°¡ host derivedÇÏ´Ù´Â °ÍÀ» ¹àÇû½À´Ï´Ù.
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https://www.sciencedirect.com/science/article/pii/S2211124724002535?pes=vor#bib12