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À̹ø ¹ßÇ¥ ³í¹®Àº ÀÛ³â 12¿ù Cell metabolism ¿¡ ÃâÆÇµÈ 'GDF15 is a major determinant of ketogenic diet-induced weight loss' ÀÔ´Ï´Ù.
Ketogenic diet (KD) Àúź¼öȹ° °íÁö¹æ ½Ä´ÜÀ¸·Î ÃÖ±Ù ¿©·¯ Áúº´¿¡ Ä¡·á È¿°ú°¡ ÀÖ´Ù°í ¾Ë·ÁÁ® ÀÖÀ¸¸ç ƯÈ÷ üÁß °¨·®, glucose tolerance, insulin resistance °³¼±À» ÅëÇØ ºñ¸¸ ȯÀÚ¿¡°Ôµµ È¿°ú°¡ ÁÁ´Ù°í ¾Ë·ÁÁ® ÀÖÀ¸³ª, ¾ÆÁ÷ Á¤È®ÇÑ mechanism Àº ¾Ë·ÁÁø ¹Ù°¡ ¾ø½À´Ï´Ù.
º» ¿¬±¸¿¡¼´Â high-fat diet (HFD) ·Î ºñ¸¸ÀÌ À¯µµµÈ mouse ¿¡ KD ¸¦ ±ÞÀÌÇÏ¿´À» °æ¿ì circulating GDF15 °¡ Áõ°¡Çϸç ÀÌ´Â energy intake, body weight, fat mass, triglyceride, glucose tolerance, and insulin resistance °¨¼Ò¿¡ Á÷Á¢ÀûÀÎ ¿ªÇÒÀ» Çϸç, GDF15 ÀÇ origin Àº liver ¶ó´Â °ÍÀ» º¸¿©ÁÖ¾ú½À´Ï´Ù.
¶ÇÇÑ KD ±ÞÀÌ ½Ã Áõ°¡ÇÑ Pparg pathway °¡ Gdf15 expression À» Á¶ÀýÇÏ´Â °ÍÀ» º¸¿©ÁÜÀ¸·Î¼ KD ÀÇ Ã¼Áß °¨¼Ò mechanism ¿¡ ´ëÇØ ¹àÈù ³í¹®ÀÔ´Ï´Ù.
¶ÇÇÑ mouse »Ó¸¸ ¾Æ´Ï¶ó pig, human ¿¡¼µµ Çö»óÀûÀÎ ºÎºÐÀ» º¸¿©ÁÖÀ¸·Î¼ mammal ¿¡¼ KD ÀÇ È¿°ú¿¡ ´ëÇØ ¹àÈ÷°í ÀÖ½À´Ï´Ù.
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https://www.cell.com/cell-metabolism/abstract/S1550-4131(23)00414-X