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"Glycoprotein non-metastatic melanoma protein B restricts PRRSV replication by inhibiting autophagosome-lysosome fusion"À̶ó´Â Á¦¸ñÀÇ ³í¹®ÀÔ´Ï´Ù.

Type 1 transmembrain ´Ü¹éÁú Áß ÇϳªÀÎ Glycoprotein non-metastatic melanoma protein B (GPNMB)´Â ¸¶Å©·ÎÆÄÁö¿¡ ¹ßÆíÇϸç, ÀÌ´Â PRRSV°¨¿°½Ã expression levelÀÌ °¨¼ÒÇÏ°Ô µÇ´Âµ¥, GPNMB ¹ßÇöÀÇ °¨¼Ò´Â autophago-lysosomeÀÇ Çü¼ºÀ» ¾ïÁ¦ÇØ PRRSVÀÇ replicationÀ» ÁõÁø½ÃŲ´Ù´Â °ÍÀ» ¹àÇû½À´Ï´Ù.

±âÁ¸¿¡ autophagosome³»¿¡¼­ replicationÀÌ Áõ°¡ÇÏ´Â PRRSVÀÇ Æ¯Â¡°ú´Â ¹Ý´ëµÇ´Â ³»¿ëÀ» ¾î¶»°Ô Ç®¾î³ª°¥Áö Èï¹Ì·Î¿î ÁÖÁ¦¿©¼­ °øºÎÇغ¸°íÀÚ ¼±Á¤ÇÏ°Ô µÇ¾ú½À´Ï´Ù. 

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