This is Mingyu Jin.
I am making this post to inform you that I will be presenting this week’s seminar (8/6).
The paper I am going to present is “Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis”.
It was published on Cell Host & Microbe in May 2019.
Sphingolipids are aliphatic amino alcohols that serve as ubiquitous structural components of all eukaryotic and some prokaryotic cell membranes. Sphingolipid-mediated metabolic and immune signaling events are implicated in autoimmune and chronic inflammatory diseases, including inflammatory bowel disease (IBD).
The full repertoire of Bacteroides sphingolipids and their roles in innate immune and metabolic pathways of chronic inflammation in the mammalian gut, however, remain largely unknown.
Based on their previous findings of dysregulated host sphingolipid metabolism during IBD (my last paper pressentation), they sought to understand the role of Bacteroides sphingolipid production in the gut during health and disease.
In characterizing the host response to bacterial sphingolipids, they discovered that a lack of bacterial sphingolipid production resulted in intestinal inflammation and changes in host sphingolipid metabolites in mice. Lipidomic analysis revealed a number of previously unknown bacterial sphingolipids that negatively correlated with IBD and inflammation in a human cohort. These data suggest sphingolipids play a role in maintaining symbiosis and homeostasis in the intestine.
With possible applications, such as in the field of interactions between metabolites (sphingolipids) and intestinal homeostasis. I believe the findings from this paper surely are interesting.
Please check out the link below to download the full paper.
https://doi.org/10.1016/j.chom.2019.04.002
Best regards.
Mingyu Jin.