Greeting,
This is Mingyu Jin.
I am making this post to inform you that I will be presenting this week’s seminar (3/5).
The paper I am going to present is “Dietary Fiber Metabolites Regulate Innate Lymphoid Cell Responses”.
It was published on Mucosal Immunology in March 2021.
Innate lymphoid cells (ILCs) rapidly undergo expansion in population size and functional maturation in response to cytokines that signal infection, tissue damage or changes in physiology. ILCs are regulated by the metabolites produced by the commensal microbiota.
In this study, the function of DF metabolites and their receptors was investigated in regulating ILCs in mucosal and systemic tissue sites.
SCFAs, produced by the commensal microbiota from dietary fibers, support optimal expansion of ILCs, including ILC1, ILC2 and ILC3 in the intestines through their G-protein-coupled receptors (GPCRs).
In addition, GPCR triggering by SCFAs co-stimulates the activation of PI3K, MEK, mTOR, STAT3, and STAT5, leading to ILC population expansion.
With possible applications, such as in the field of nutritional and microbial status in shaping the peripheral ILC system. I believe the findings from this paper surely are interesting.
Please check out the link below to download the full paper.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736174/
Best regards.
Mingyu Jin.
This is Mingyu Jin.
I am making this post to inform you that I will be presenting this week’s seminar (3/5).
The paper I am going to present is “Dietary Fiber Metabolites Regulate Innate Lymphoid Cell Responses”.
It was published on Mucosal Immunology in March 2021.
Innate lymphoid cells (ILCs) rapidly undergo expansion in population size and functional maturation in response to cytokines that signal infection, tissue damage or changes in physiology. ILCs are regulated by the metabolites produced by the commensal microbiota.
In this study, the function of DF metabolites and their receptors was investigated in regulating ILCs in mucosal and systemic tissue sites.
SCFAs, produced by the commensal microbiota from dietary fibers, support optimal expansion of ILCs, including ILC1, ILC2 and ILC3 in the intestines through their G-protein-coupled receptors (GPCRs).
In addition, GPCR triggering by SCFAs co-stimulates the activation of PI3K, MEK, mTOR, STAT3, and STAT5, leading to ILC population expansion.
With possible applications, such as in the field of nutritional and microbial status in shaping the peripheral ILC system. I believe the findings from this paper surely are interesting.
Please check out the link below to download the full paper.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736174/
Best regards.
Mingyu Jin.
Dietary fiber metabolites regulate innate lymphoid cell responses.pdf