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Á¦°¡ À̹ø¿¡ ¹ßÇ¥ ÇÒ ³í¹®Àº ¿ÃÇØ cell reports¿¡ ÃâÆÇ µÈ,

" Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection" ÀÔ´Ï´Ù.

ÀÌ ³í¹®¿¡¼­´Â obesity »óȲ ½Ã, viral infectionÀÌ white adipose tissue(WAT) T cell¿¡ ¾î¶°ÇÑ ¿µÇâÀ» ÁÖ´ÂÁö ¾Ë¾Æº¸°íÀÚ ÇÏ¿´½À´Ï´Ù.

AT¿¡ Á¸ÀçÇÏ´Â virus-specific T cellÀº lymphoid tissue¿Í ´Ù¸£°Ô phenotype marker¸¦ ¹ßÇöÇϸç,

Obesity + infection »óȲ ½Ã memory T cellÀÇ Áõ°¡¿Í ´õºÒ¾î T cell-dependent pathogenic response¸¦ È®ÀÎ ÇÏ¿´½À´Ï´Ù.

 

ÀÌ ³í¹®À» ¼±Á¤ÇÑ ÀÌÀ¯´Â

- ¸é¿ªÇÐÀû Ãø¸é¿¡¼­ adipose tissue°¡ ÇÏ´Â ¿ªÇÒÀÌ ¹«¾ùÀÏÁö °í¹ÎÇÏ´ø Áß ÀÌ¿¡ ´ëÇØ ¾Ë¾Æº¸°íÀÚ

±âÁ¸¿¡´Â ÁÖ·Î adipose tissue¿Í macrophage¿¡ ÃÊÁ¡À» ¸ÂÃß¾î °øºÎÇߴµ¥, ´Ù¸¥ ¸é¿ª¼¼Æ÷´Â ¾î¶²Áö °øºÎÇÏ°íÀÚ

- ¶ÇÇÑ ÀÌ ³í¹®¿¡¼­ »ç¿ëÇÑ ºÐ¼® ¹æ¹ýÀ» Âü°íÇÏ°íÀÚ ¼±Á¤ÇÏ¿´½À´Ï´Ù.

 

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³í¹® ¸µÅ©: https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30346-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124719303468%3Fshowall%3Dtrue

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¾È³çÇϼ¼¿ä ³ª·¡ÀÔ´Ï´Ù.À̹øÁÖ ¹ßÇ¥³í¹®Àº Áö³­ÇØ frontiers in immunology¿¡ °ÔÀçµÈ"Downregulation of SLC7A7 Triggers an Inflammatory Phenotype in Human Macrophages and Airway Epithelial Cells" À̶ó´Â Á¦¸ñÀÇ ³í¹®À¸·Îamino acid transporterÀÇ ÇÑ Á¾·ùÀÎ SLC7A7ÀÇ °áÇÌÀÌ human epithelial cell°ú macrophageÀÇ ..