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2021-06-18
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À̹ø Åä¿äÀÏ¿¡ Á¦°¡ ¹ßÇ¥ÇÒ ³í¹®Àº 

2017³â immunity¿¡ ÃâÆǵȠ

'Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals' ÀÔ´Ï´Ù.

 

Gut homeostasis¿¡ IgAÀÇ ¿ªÇÒÀº ¸¹Àº ¿¬±¸°¡ µÇ¾úÀ¸¸ç À̸¦ »ý¼ºÇÏ´Â plasma cellµéÀÇ ´ëÇÑ ¿ªÈ° ¹× ontogeny ¶ÇÇÑ ¿¬±¸°¡ ÀßµÇ¾î ¿Ô½À´Ï´Ù.

ÇÏÁö¸¸ Àå¿¡´Â IgM ¶ÇÇÑ Á¸À縦 Çϸç IgA°¡ ºÎÁ·ÇÑ È¯ÀÜ¿¡¼­ IgMÀÌ compensatoryÇÏ°Ô ±× ¿ªÇÒÀ» ¼öÇàÇÔ¿¡ µû¶ó IgMÀÇ ¿ªÇÒ ¶ÇÇÑ ÃÖ±Ù ¿¬±¸°¡ ÁøÇàµÇ°í ÀÖ½À´Ï´Ù.

ÇÏÁö¸¸ ¾ÆÁ÷ human gut IgM ¹× À̸¦ »ý¼ºÇÏ´Â plasma cell¿¡ ´ëÇÑ ¿¬±¸°¡ Àß µÇ¾î ÀÖÁö ¾Ê¾Æ 

º» ¿¬±¸¿¡¼±´À IgMÀ» »ý¼ºÇÏ´Â plasma cellÀÇ »ý¼º ¹× ¿ªÇÒ¿¡ ´ëÇÏ¿© ¿¬±¸¸¦ ÁøÇàÇÏ¿´½À´Ï´Ù.

 

¿­½ÉÈ÷ ÁغñÇÏ¿© ¹ßÇ¥Çϵµ·Ï ÇÏ°Ú½À´Ï´Ù.

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±â¼± ¿Ã¸²

³í¹®¸µÅ©: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519504/

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