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" CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma " ÀÔ´Ï´Ù.

ÇØ´ç ³í¹®¿¡¼­ CD200-CD200R engagement´Â ILC2 ÀÇ effector fuctionÀÌ °¨¼ÒµÊÀ» È®ÀÎÇÏ¿©,
CD200RÀÌ ILC2¸¦ Á¶ÀýÇÏ´Â Áß¿äÇÑ regulatorÀÓÀ» ¹àÇû½À´Ï´Ù.
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CD200R-target agonistic Ä¡·á´Â »õ·Î¿î õ½ÄÄ¡·á¹æ¹ýÀÌ µÉ ¼ö ÀÖÀ½À» ½Ã»çÇÏ¿´½À´Ï´Ù.

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https://www.nature.com/articles/s41467-021-22832-7
 
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À̹ø¿¡ Á¦°¡ ¹ßÇ¥µå¸± ³í¹®ÀÇ Á¦¸ñÀº "Complement C5a promotes antigen cross- presentation by Peyer’s patch monocyte-derived dendritic cells and drives a protective CD8+ T cell response" À̸ç Áö³­´Þ Cell Report¿¡ º¸°íµÇ¾ú½À´Ï´Ù Peyer's patch¿¡ ÀÖ´Â µ¶µæÇÑ DCÀÎ LysoDC¿¡¼­. ÀÌÀü¿¡..