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Research

 Studies on the quorum sensing regulatory network and biofilm control

1. Kim, Y. J., Kim. B. S., Park. Y. J., Choi. W. C., Hwang. J. W., Kang. B. S., Oh. T. W., Choi. S. H., Kim. M. Y. 2010. Crystal structure of SmcR, s Quorum- sensing Master Regulator of Vibrio vulnificus, Provides Insight into Its Regulation of Transcription. J. Biol. Chem. 285(18):14020-14030.

2. Jeong, H. S., S. M. Kim, M. S. Lim, K. S. Kim, and S. H. Choi. 2010. Direct Interaction between Quorum Sensing Regulator SmcR and RNAP Is Mediated by IHF to Activate vvpE Encoding Elastase in Vibrio vulnificus. J. Biol. Chem. 285(13): 9357-9366.

3. Oh, M.H., S.M. Lee, D.H. Lee, and S.H. Choi. 2009. Regulation of the Vibrio vulnificus hupA gene by temperature alteration and cyclic AMP receptor protein and evaluation of its role in virulence. Infec. Immun. 77: 1208-1215.

4. Jeong, H.G., M.H. Oh, B.S. Kim, M.Y. Lee, H.J. Han, and S.H. Choi. 2009. The capability of catabolic utilization of N-Acetylneuraminic acid, a salic acid, is essential for Vibrio vulnificus pathogenesis. Infec. Immun. 77: 3209-3217.

5. Lee, D. H., H. S. Jeong, H. G. Jeong, K. M. Kim, H. Kim, and S. H. Choi. 2008. A consensus sequence for binding of SmcR, a Vibrio vulnificus LuxR homologue and genomewide indentification of the SmcR regulon. J. Biol. Chem. 283(35): 23610-23618.
 
 Characterization of oxidative stress defense network of Vibrio vulnificus

1. Kho, M. J., H. S. Lee, J. E. Rhee, and S. H. Choi. 2010. Evidence That Vibrio vulnificus AhpC2 Is Essential for Survival Under High Salinity by Modulating Intracellular Level of ROS. J Microbiol. 48(1): 129-133.

2. Baek, W.K., H.S. Lee, M.H. Oh, M.J. Koh, K.S. Kim, and S.H. Choi 2009. Identification of the Vibrio vulnificus ahpC1 Gene and Its Influence on Survival under Oxidative Stress and Virulence. J. Microbiol. 47(5): 624-632.
 
 Genome-wide identification and characterization of Vibrio vulnificus virulence factor using NGS (next-generation sequencing) technology

1. Park, J.H., Y. J. Cho, J. Chun, Y. J. Seok, J. K. Lee, K. S. Kim, K. H. Lee, S. J. Park, and S. H. Choi. 2011. Complete Genome Sequence of Vibrio vulnificus M06-24/O. J. Bacteriol. 193:2062-2063.
 
 Establishment of Food Safety and Security in Korea (식품안전 첨단 기술 개발과 교육을 통한 식품안전 기반 구축)