HOME > Publication > Publication
2023
41. iPSC-Derived MSCs Are a Distinct Entity of MSCs with Higher Therapeutic Potential than Their Donor-Matched Parental MSCs
Lee HR, Kim S, Shin S, Jeong SY, Lee DW, Lim SU, Kang JY, Son MY, Lee C, Yu KR, Kim M, Oh IH. iPSC-Derived MSCs Are a Distinct Entity of MSCs with Higher Therapeutic Potential than Their Donor-Matched Parental MSCs. Int J Mol Sci. 2023 Jan 3;24(1):881. doi: 10.3390/ijms24010881. PMID: 36614321; PMCID: PMC9821152.
2022
40. A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions
Shin TH, Zhou Y, Chen S, Cordes S, Grice MZ, Fan X, Lee BC, Aljanahi AA, Hong SG, Vaughan KL, Mattison JA, Kohama SG, Fabre MA, Uchida N, Demirci S, Corat MAF, Métais JY, Calvo KR, Buscarlet M, Natanson H, McGraw KL, List AF, Busque L, Tisdale JF, Vassiliou GS, Yu KR, Dunbar CE. A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions. Blood. 2022 Oct 20;140(16):1774-1789. doi: 10.1182/blood.2021014875. PMID: 35714307; PMCID: PMC9837449.
39. Prediction and validation of hematopoietic stem and progenitor cell off-target editing in transplanted rhesus macaques
AlJanahi AA, Lazzarotto CR, Chen S, Shin TH, Cordes S, Fan X, Jabara I, Zhou Y, Young DJ, Lee BC, Yu KR, Li Y, Toms B, Tunc I, Hong SG, Truitt LL, Klermund J, Andrieux G, Kim MY, Cathomen T, Gill S, Tsai SQ, Dunbar CE. Prediction and validation of hematopoietic stem and progenitor cell off-target editing in transplanted rhesus macaques. Mol Ther. 2022 Jan 5;30(1):209-222. doi: 10.1016/j.ymthe.2021.06.016. Epub 2021 Jun 24. PMID: 34174439; PMCID: PMC8753565.
38. Diesel Exhaust Particles Impair Therapeutic Effect of Human Wharton`s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis through ROS/ERK/cFos Signaling Pathway
Park, H. S., Oh, M. K., Lee, J. W., Chae, D. H., Joo, H., Kang, J. Y., An, H. B., Yu, A., Park, J. H., Yoo, H. M., Jung, H. J., Choi, U., Jung, J. W., Kim, I. S., Oh, I. H., & Yu, K. R. (2021). International journal of stem cells, 10.15283/ijsc21178
2021
37. Anticancer Effects of Propionic Acid Inducing Cell Death in Cervical Cancer Cells
Pham, C. H., Lee, J. E., Yu, J., Lee, S. H., Yu, K. R., Hong, J., Cho, N., Kim, S., Kang, D., Lee, S., & Yoo, H. M. (2021). Anticancer Effects of Propionic Acid Inducing Cell Death in Cervical Cancer Cells. Molecules (Basel, Switzerland), 26(16), 4951. https://doi.org/10.3390/molecules26164951
36. SMARCA4 oncogenic potential via IRAK1 enhancer to activate Gankyrin and AKR1B10 in liver cancer
Kim, S. Y., Shen, Q., Son, K., Kim, H. S., Yang, H. D., Na, M. J., Shin, E., Yu, S., Kang, K., You, J. S., Yu, K. R., Jeong, S. M., Lee, E. K., Ahn, Y. M., Park, W. S., & Nam, S. W. (2021). Oncogene. doi:10.1038/s41388-021-01875-6
35. Extracellular Vesicles from Thapsigargin-Treated Mesenchymal Stem Cells Ameliorated Experimental Colitis via Enhanced Immunomodulatory Properties
Joo, H., Oh, M. K., Kang, J. Y., Park, H. S., Chae, D. H., Kim, J., Lee, J. H., Yoo, H. M., Choi, U., Kim, D. K., Lee, H., Kim, S., & Yu, K. R. (2021). Biomedicines, 9(2). doi:10.3390/biomedicines9020209
34. Comparative engraftment and clonality of macaque HSPCs expanded on human umbilical vein endothelial cells versus non-expanded cells
Srivastava, S. K., Truitt, L. L., Wu, C., Glaser, A., Nolan, D. J., Ginsberg, M., Espinoza, D. A., Koelle, S., Yabe, I. M., Yu, K. R., Hong, S., Sellers, S., Krouse, A., Bonifacino, A., Metzger, M., Dagur, P. K., Donahue, R. E., Dunbar, C. E., & Panch, S. R. (2021). Mol Ther Methods Clin Dev, 20, 703-715. doi:10.1016/j.omtm.2021.02.009
33. Therapeutic Features and Updated Clinical Trials of Mesenchymal Stem Cell (MSC)-Derived Exosomes
Lee, B. C., Kang, I., & Yu, K. R. (2021). J Clin Med, 10(4). doi:10.3390/jcm10040711
2020
32. Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton's Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity
Kang, J. Y., Oh, M. K., Joo, H., Park, H. S., Chae, D. H., Kim, J., Lee, H. R., Oh, I. H., & Yu, K. R. (2020). J Clin Med, 9(9). doi:10.3390/jcm9092913
31. Impact of mesenchymal stem cell senescence on inflammaging.
Lee, B. C., & Yu, K. R. (2020). BMB Rep, 53(2), 65-73. doi:10.5483/BMBRep.2020.53.2.291
2019
29. CRISPR/Cas9 PIG -A gene editing in nonhuman primate model demonstrates no intrinsic clonal expansion of PNH HSPCs.
Shin TH*, Baek EJ*, Corat MAF, Chen S, Metais JY, Aljanahi AA, Zhou Y, Donahue RE, Yu KR, Dunbar CE.
2018
28. Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity.
Yabe IM, Truitt LL, Espinoza DA, Wu C, Koelle S, Panch S, Corat MAF, Winkler T, Yu KR, Hong SG, Bonifacino A, Krouse A, Metzger M, Donahue RE, Dunbar CE. Mol Ther Methods Clin Dev. 2018 Dec 14;11:143-154. doi: 10.1016/j.omtm.2018.10.009. eCollection 2018 Dec 14. PubMed PMID: 30547048; PubMed Central PMCID: PMC6258888.
27. Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Kim MY, Yu KR, Kenderian SS, Ruella M, Chen S, Shin TH, Aljanahi AA, Schreeder D, Klichinsky M, Shestova O, Kozlowski MS, Cummins KD, Shan X, Shestov M, Bagg A, Morrissette JJD, Sekhri P, Lazzarotto CR, Calvo KR, Kuhns DB, Donahue RE, Behbehani GK, Tsai SQ, Dunbar CE, Gill S. Cell. 2018 May 31;173(6):1439-1453.e19. doi: 10.1016/j.cell.2018.05.013. Epub 2018 May 31. PubMed PMID: 29856956; PubMed Central PMCID: PMC6003425.
26. GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging.
Lee JY, Yu KR, Lee BC, Kang I, Kim JJ, Jung EJ, Kim HS, Seo Y, Choi SW, Kang KS. Exp Mol Med. 2018 May 14;50(5):63. doi: 10.1038/s12276-018-0092-3. PubMed PMID: 29760459; PubMed Central PMCID: PMC5951912.
25. The impact of aging on primate hematopoiesis as interrogated by clonal tracking.
Yu KR, Espinoza DA, Wu C, Truitt L, Shin TH, Chen S, Fan X, Yabe IM, Panch S, Hong SG, Koelle S, Lu R, Bonifacino A, Krouse A, Metzger M, Donahue RE, Dunbar CE. Blood. 2018 Mar 15;131(11):1195-1205. doi: 10.1182/blood-2017-08-802033. Epub 2018 Jan 2. PubMed PMID: 29295845; PubMed Central PMCID: PMC5855019.
2017
24. Direct Conversion of Human Umbilical Cord Blood into Induced Neural Stem Cells with SOX2 and HMGA2.
Kim JJ, Shin JH, Yu KR, Lee BC, Kang I, Lee JY, Kim DH, Seo Y, Kim HS, Choi SW, Kang KS. Int J Stem Cells. 2017 Nov 30;10(2):227-234. doi: 10.15283/ijsc17025. PubMed PMID: 28844127; PubMed Central PMCID: PMC5741203.
23. Generation of patient specific human neural stem cells from Niemann-Pick disease type C patient-derived fibroblasts.
Sung EA, Yu KR, Shin JH, Seo Y, Kim HS, Koog MG, Kang I, Kim JJ, Lee BC, Shin TH, Lee JY, Lee S, Kang TW, Choi SW, Kang KS. Oncotarget. 2017 Oct 17;8(49):85428-85441. doi: 10.18632/oncotarget.19976. eCollection 2017 Oct 17. PubMed PMID: 29156730; PubMed Central PMCID: PMC5689620.
2016
22. Gene Editing of Human Hematopoietic Stem and Progenitor Cells: Promise and Potential Hurdles.
Yu KR, Natanson H, Dunbar CE. Hum Gene Ther. 2016 Oct;27(10):729-740. doi: 10.1089/hum.2016.107. Epub 2016 Aug 2. Review. PubMed PMID: 27483988; PubMed Central PMCID: PMC5035911.
21. BMI1 inhibits senescence and enhances the immunomodulatory properties of human mesenchymal stem cells via the direct suppression of MKP-1/DUSP1.
Lee JY, Yu KR, Kim HS, Kang I, Kim JJ, Lee BC, Choi SW, Shin JH, Seo Y, Kang KS. Aging (Albany NY). 2016 Aug;8(8):1670-89. doi: 10.18632/aging.101000. PubMed PMID: 27454161; PubMed Central PMCID: PMC5032689.
20. PGE2 maintains self-renewal of human adult stem cells via EP2-mediated autocrine signaling and its production is regulated by cell-to-cell contact.
Lee JY, Yu KR, Kim HS, Kang I, Kim JJ, Lee BC, Choi SW, Shin JH, Seo Y, Kang KS. Aging (Albany NY). 2016 Aug;8(8):1670-89. doi: 10.18632/aging.101000. PubMed PMID: 27454161; PubMed Central PMCID: PMC5032689.
2015
19. miR-410 Inhibition Induces RPE Differentiation of Amniotic Epithelial Stem Cells via Overexpression of OTX2 and RPE65.
Choi SW, Kim JJ, Seo MS, Park SB, Kang TW, Lee JY, Lee BC, Kang I, Shin TH, Kim HS, Yu KR, Kang KS. Stem Cell Rev. 2015 Jun;11(3):376-86. doi: 10.1007/s12015-014-9568-2. PubMed PMID: 25351180.
18. Hman mbilical cord blood mesenchymal stem cell-derived PGE2 and TGF-β1 alleviate atopic dermatitis by reducing mast cell degranulation.
Kim HS, Yun JW, Shin TH, Lee SH, Lee BC, Yu KR, Seo Y, Lee S, Kang TW, Choi SW, Seo KW, Kang KS. Stem Cells. 2015 Apr;33(4):1254-66. doi: 10.1002/stem.1913. PubMed PMID: 25522163.
17. DNA methyltransferase inhibition accelerates the immunomodulation and migration of human mesenchymal stem cells.
Lee S, Kim HS, Roh KH, Lee BC, Shin TH, Yoo JM, Kim YL, Yu KR, Kang KS, Seo KW. Sci Rep. 2015 Jan 26;5:8020. doi: 10.1038/srep08020. PubMed PMID: 25620445; PubMed Central PMCID: PMC4306122.
16. Rapid and Efficient Direct Conversion of Human Adult Somatic Cells into Neural Stem Cells by HMGA2/let-7b.
Yu KR, Shin JH, Kim JJ, Koog MG, Lee JY, Choi SW, Kim HS, Seo Y, Lee S, Shin TH, Jee MK, Kim DW, Jung SJ, Shin S, Han DW, Kang KS. Cell Rep. 2015 Jan 20;10(3):441-452. doi: 10.1016/j.celrep.2014.12.038. Epub 2015 Jan 15. PubMed PMID: 25600877.
2014~
15. miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18.
Lee S, Yu KR, Ryu YS, Oh YS, Hong IS, Kim HS, Lee JY, Kim S, Seo KW, Kang KS. Age (Dordr). 2014;36(6):9724. doi: 10.1007/s11357-014-9724-2. Epub 2014 Dec 4. PubMed PMID: 25465621; PubMed Central PMCID: PMC4259092.
14. Excessive microglial activation aggravates olfactory dysfunction by impeding the survival of newborn neurons in the olfactory bulb of Niemann-Pick disease type C1 mice.
Seo Y, Kim HS, Shin Y, Kang I, Choi SW, Yu KR, Seo KW, Kang KS. Biochim Biophys Acta. 2014 Nov;1842(11):2193-203. doi: 10.1016/j.bbadis.2014.08.005. Epub 2014 Aug 15. PubMed PMID: 25132229.
13. A p38 MAPK-mediated alteration of COX-2/PGE2 regulates immunomodulatory properties in human mesenchymal stem cell aging.
Yu KR, Lee JY, Kim HS, Hong IS, Choi SW, Seo Y, Kang I, Kim JJ, Lee BC, Lee S, Kurtz A, Seo KW, Kang KS. PLoS One. 2014;9(8):e102426. doi: 10.1371/journal.pone.0102426. eCollection 2014. PubMed PMID: 25090227; PubMed Central PMCID: PMC4121064.
12. Growth arrest and forced differentiation of human primary glioblastoma multiforme by a novel small molecule.
Kang TW, Choi SW, Yang SR, Shin TH, Kim HS, Yu KR, Hong IS, Ro S, Cho JM, Kang KS. Sci Rep. 2014 Jul 3;4:5546. doi: 10.1038/srep05546. PubMed PMID: 24989033; PubMed Central PMCID: PMC4080225.
11. Donepezil enhances Purkinje cell survival and alleviates motor dysfunction by inhibiting cholesterol synthesis in a murine model of Niemann Pick disease type C.
Seo Y, Shin Y, Kim HS, Kang I, Hong IS, Choi SW, Yu KR, Kang KS. J Neuropathol Exp Neurol. 2014 Mar;73(3):234-43. doi: 10.1097/NEN.0000000000000045. PubMed PMID: 24487798.
10. Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2.
Kim HS, Shin TH, Lee BC, Yu KR, Seo Y, Lee S, Seo MS, Hong IS, Choi SW, Seo KW, Núñez G, Park JH, Kang KS. Gastroenterology. 2013 Dec;145(6):1392-403.e1-8. doi: 10.1053/j.gastro.2013.08.033. Epub 2013 Aug 21. PubMed PMID: 23973922.
9. MicroRNA-141-3p plays a role in human mesenchymal stem cell aging by directly targeting ZMPSTE24.
Yu KR, Lee S, Jung JW, Hong IS, Kim HS, Seo Y, Shin TH, Kang KS. J Cell Sci. 2013 Dec 1;126(Pt 23):5422-31. doi: 10.1242/jcs.133314. Epub 2013 Oct 7. PubMed PMID: 24101728.
8. The effects of hedgehog on RNA binding protein Msi1 during the osteogenic differentiation of human cord blood-derived mesenchymal stem cells.
Hong IS, Lee HY, Choi SW, Kim HS, Yu KR, Seo Y, Jung JW, Kang KS. Bone. 2013 Oct;56(2):416-25. doi: 10.1016/j.bone.2013.07.016. Epub 2013 Jul 20. PubMed PMID: 23880227.
7. Aging-related genes in mesenchymal stem cells: a mini-review. Gerontology. 2013;59(6):557-63. doi: 10.1159/000353857.
Yu KR, Kang KS. Aging-related genes in mesenchymal stem cells: a mini-review. Gerontology. 2013;59(6):557-63. doi: 10.1159/000353857. Epub 2013 Aug 17. Review. PubMed PMID: 23970150.
6. HMGA2 regulates the in vitro aging and proliferation of human umbilical cord blood-derived stromal cells through the mTOR/p70S6K signaling pathway.
Yu KR, Park SB, Jung JW, Seo MS, Hong IS, Kim HS, Seo Y, Kang TW, Lee JY, Kurtz A, Kang KS. Stem Cell Res. 2013 Mar;10(2):156-65. doi: 10.1016/j.scr.2012.11.002. Epub 2012 Nov 16. PubMed PMID: 23276696.
5. CD49f enhances multipotency and maintains stemness through the direct regulation of OCT4 and SOX2.
Yu KR, Yang SR, Jung JW, Kim H, Ko K, Han DW, Park SB, Choi SW, Kang SK, Schöler H, Kang KS. Stem Cells. 2012 May;30(5):876-87. doi: 10.1002/stem.1052. PubMed PMID: 22311737.
4. SOX2 has a crucial role in the lineage determination and proliferation of mesenchymal stem cells through Dickkopf-1 and c-MYC.
Park SB, Seo KW, So AY, Seo MS, Yu KR, Kang SK, Kang KS. Cell Death Differ. 2012 Mar;19(3):534-45. doi: 10.1038/cdd.2011.137. Epub 2011 Oct 21. PubMed PMID: 22015605; PubMed Central PMCID: PMC3278737.
3. Human umbilical cord blood mesenchymal stem cell-derived extracellular matrix prohibitsmetastatic cancer cell MDA-MB-231 proliferation.
Sun B, Yu KR, Bhandari DR, Jung JW, Kang SK, Kang KS. Cancer Lett. 2010 Oct 28;296(2):178-85. doi: 10.1016/j.canlet.2010.04.007. PubMed PMID: 20435406.
2. bFGF enhances the IGFs-mediated pluripotent and differentiation potentials in multipotent stem cells.
Park SB, Yu KR, Jung JW, Lee SR, Roh KH, Seo MS, Park JR, Kang SK, Lee YS, Kang KS. Growth Factors. 2009 Dec;27(6):425-37. doi: 10.3109/08977190903289875. PubMed PMID: 19919531.
1. Isolation and characterization of canine umbilical cord blood-derived mesenchymal stem cells.
Seo MS, Jeong YH, Park JR, Park SB, Rho KH, Kim HS, Yu KR, Lee SH, Jung JW, Lee YS, Kang KS. J Vet Sci. 2009 Sep;10(3):181-7. doi: 10.4142/jvs.2009.10.3.181. PubMed PMID: 19687617; PubMed Central PMCID: PMC2801133